Neonatal Research Institute
Clinical Trials at the Neonatal Research Institute
The Neonatal Research Institute was established to identify and disseminate the latest evidence-based best practices for newborn care. At Sharp Mary Birch, the busiest maternity hospital in California, we have a unique opportunity to research new, leading-edge treatments and practices. Learn more about our clinical trials.
Current trials:
- Milking or delayed cord clamping
- Multicenter, randomized trial of preterm infants receiving caffeine and less invasive surfactant administration compared to caffeine and early continuous positive airway pressure (CaLI trial)
- PFAS in human breastmilk
- Physiological changes with high-flow nasal cannula compared to nasal CPAP in extremely low birth weight infants
- Safety of manganese restriction in neonatal parenteral nutrition
- Tedizolid pharmacokinetics in pediatric participants with Gram-positive infections
- Umbilical cord milking in non-vigorous infants
Completed trials:
- 3-D imaging of babies
- Aerosolized Infasurf
- Antibiotic safety in infants with complicated intra-abdominal infections
- Changes in cardiac output during delayed cord clamping
- Closed system for colostrum collection
- Comparative and reference range study of the UBCheck unbound bilirubin assay for neonatal jaundice
- Dalbavancin pharmacokinetics in preterm and term neonates
- Early caffeine versus routine administration of caffeine on the need for ventilation and cardiac support in preterm babies
- Effectiveness of Infinity Acute Care System
- Effects of prolonged intubation attempts on oxygen saturation and heart rate in preterm infants in the delivery room
- FORE-SIGHT Elite Absolute Tissue Oximeter to measure cerebral and somatic tissue oxygen saturation measurements at different body locations on babies
- Immediate cord clamping versus enhanced placental transfusion on early respiratory support and patent ductus arteriosus outcomes
- Lucinactant for inhalation in preterm babies (26 to 32 weeks gestational age) with respiratory distress syndrome
- Lucinactant for inhalation in preterm babies (26 to 28 weeks gestational age)
- Lucinactant for inhalation in preterm babies (29 to 34 weeks gestational age): dose escalation and study extension
- Milking or delayed cord clamping in premature infants
- Neonatal resuscitation with intact cord
- Neuromonitoring of preterm newborn brain during birth resuscitation
- Prediction of newborn brain injury risk
- Premature infants resuscitated with oxygen or air
- Seizure detection in babies
- Short-delayed cord clamping compared to extended-delayed cord clamping in term infants needing resuscitation
- Sustained inflation in the delivery room
- Treatment of ductus arteriosus
- Treatment of neonatal seizures